Crafted for those who want the best in potent, plant-based extracts, our products are made from the Mitragyna speciosa plant, delivering high levels of key compounds for maximum benefits.
At 7OHVendor, we offer high-quality options in different forms, including chewable tablets. Each batch is carefully tested for purity, and our labels provide clear dosage and usage info. We use only the best alkaloids to boost effectiveness while reducing unwanted effects.
For safe use, talk to your doctor first, especially if you’re on other medications. Always stick to the recommended amounts.
Our products are just the way to take them—it’s the alkaloids that make the difference. Let’s dive into what these powerful natural compounds can do for you.
Introduction
The Mitragyna speciosa tree indigenous to Southeast Asia, has been used for centuries for its potential benefits. This tropical plant, belonging to the coffee family, is known for its potent alkaloids, primarily mitragynine and 7-hydroxymitragynine, which interact with opioid receptors in the brain, offering a range of effects from relief feelings to mood enhancement.
Since the 1930s, pseudo alkaloids from found in plants has been cited as an opium substitute according to research conducted by H. Burkill and Mohamad Haniff published in Gardens’ Bulletin, Straits Settlements (1930). Since some of the plants with the highest-type of alkaloids are primarily used as a remedy in Southeast Asia, it has grown in popularity and adoption worldwide, sparking interest by researchers to further study the plant and alkaloids derived for treating such conditions, as well as uncovering new potential advancements in alternative medicine.
Though mitragynine and 7-hydroxymitragynine are the most studied alkaloid preparations for their pharmacological actions, a 2021 article published in Bioactive Natural Products showed that more than 50 alkaloids have been discovered in the the alkaloid-rich plant so far.
Mitragyna speciosa is a remarkable terpenoid indole alkaloid source. In recent years, it has gained widespread attention for its unique properties.
Derived from alkaloid-rich leaves, the active metabolite mitragynine and its more potent oxidized derivative, 7-hydroxymitragynine, work with the brain’s opioid receptors to provide users with discomfort relief, enhanced feelings, and an enjoyable experience.
What are alkaloids?
Alkaloids are natural chemicals found in living things, mostly plants, that usually have nitrogen in them. They act like bases (similar to baking soda), but some can be neutral or slightly acidic. Even some man-made chemicals with a similar structure to these natural ones can be called alkaloids.
Which are popular alkaloids examples?
Here are some examples of alkaloids and where they come from:
- Caffeine – found in coffee and tea.
- Nicotine – comes from tobacco.
- Morphine – comes from the opium poppy.
- Quinine – found in the bark of the cinchona tree.
- Strychnine – a toxic substance used in some pest control.
- Atropine – comes from plants like deadly nightshade.
- Ephedrine – found in the ephedra plant, often used in traditional medicine.
- Solanine – found in potatoes, especially in the green parts.
- Colchicine – comes from the meadow saffron plant.
- Piperine – found in black pepper.
Each of these has its own effects and uses, ranging from pain relief to stimulating the body, or even being used in medicines.
In the he Mitragyna speciosa tree, alkaloids are naturally occurring compounds found primarily in the leaves. These alkaloids exhibit a range of pharmacological effects, which can vary significantly depending on their chemical structure and the specific receptors they interact with in the body.
What do alkaloids do to the human body?
Alkaloids can affect the body in different ways, both good and bad:
- Toxic Effects: Some alkaloids can be harmful. The level of danger depends on how much you take, how long you’re exposed, and your own body’s reaction. Small amounts can cause nausea, vomiting, or itching. Long-term exposure can lead to more serious problems like paralysis, birth defects, or even death.
- Medical Uses: Many alkaloids are used in medicine to treat various diseases. For example, berberine might help treat conditions like Alzheimer’s, Parkinson’s, Huntington’s, and epilepsy.
- Biological Effects: Alkaloids can act in different ways in the body, such as reducing pain, relaxing muscles, fighting bacteria, lowering inflammation, acting as an antioxidant, or even affecting mood and sleep.
- Taste: Most alkaloids taste bitter, which is why people usually dislike foods with a bitter taste. This could be because our bodies are naturally cautious about bitter flavors, or because eating bitter things sometimes makes us feel sick afterward.
What are advanced alkaloids?
Advanced alkaloids is a term that has been used as a marketing term by other companies, though it actually is more than that.
Advanced alkaloids we’re referring to for the remainder of this is guide are the specific compounds formulated though also found naturally in the Mitragyna speciosa plant that exhibit enhanced properties, superior potency, or altered effects compared to traditional alkaloids.
What’s the use for the other alkaloids?
With over 50 other alkaloids found in just Mitragyna speciosa, the combination of those alkaloids lead experts to coin the phrase “entourage effect” where the combined compounds enhance the overall effectiveness and therapeutic potential of the plant. Those alkaloids can also be synthesized which though makes them unnaturally more powerful than those found in the plant, the effects are derived from the chemical structure based on Mother Nature’s compounds.
This synergy of alkaloids together may offer a more balanced experience for users, as each alkaloid contributes unique properties that can support, amplify, or mitigate the effects of others harmoniously.
All About Alkaloids in Mitragyna speciosa
Alkaloids as the building blocks, and having a better understanding of the alkaloids-derived help you to grasp the fundamentals. We’ll talk all about the most prevalent ones found in the plant.
Top 20 Mitragyna speciosa Alkaloids List
Let’s start with the most common alkaloids and associate their alkaloid type.
| Compound | Alkaloid Type |
| mitragynine | indole |
| 7-hydroxymitragynine | indole |
| mitragynine pseudoindoxyl | oxidative rearrangement |
| speciociliatine | stereoisomer |
| paynantheine | indole |
| mitraphylline | oxindole derivative |
| corynoxine | oxindole |
| speciogynine | diastereomer |
| speciofoline | oxindole |
| mitraciliatine | diastereomer |
| corynoxine b | oxindole |
| corynantheidine | indole |
| ajmalicine | indole |
| mitragynine oxindole b | oxindole |
| tetrahydroalstonine | indole |
| isopaynantheine | diastereomer |
| isorynchophylline | oxindole |
| isospeciofoline | oxindole |
| mitragynine n-oxide | oxidative derivative |
| speciociliatine n-oxide | N-oxide |
Most Popular Compounds
Starting with the most popular Mitragyna speciosa compounds, we’ll cover Mitragynine, 7-hydroxymitragynine and Mitragynine Pseudoindoxyl to get you a solid foundation for understanding.
Mitragynine
Mitragynine is the most abundant indole alkaloid in Mitragyna speciosa leaves. It is responsible for many of the psychoactive and relieving effects according to a 2019 study published in Asian Journal of Psychiatry. That study was published after a 2015 article published in Addiction Biology explained that although mitragynine has therapeutic potential, long-term use may lead to dependence, tolerance, and cognitive impairments similar to those observed with traditional opioids. Its abuse potential is being studied due to its increasing use in the West.
7-hydroxymitragynine
The alkaloid that is top-of-mind for many shoppers is 7-hydroxymitragynine due to its powerful effects and mood-enhancing properties. According to a 2017 study published in Neuropharmacology, 7-hydroxymitragynine was found to be approximately 40 times more potent than mitragynine and 10 times more potent than morphine.
Reports about 7-Hydroxymitragynine being present in smaller amounts compared to mitragynine in both natural leaves and commercial products have been established since a 2016 article published in Journal of Medical Toxicology, in which they reveal the approach of product adulteration where 7-Hydroxymitragynine levels are artificially elevated to enhance potency. Today, many of the 7 hydroxymitragynine products for sale are using either of these methods to produce products for the market.
If/when taking 7-Hydroxymitragynine, be mindful of the recommending 7-hydroxymitragynine dosage as you want to remain on the safe side.
7-Hydroxymitragynine has a higher potential for abuse than mitragynine, as it mimics the effects of traditional opioids more closely. Studies have shown that this alkaloid can induce self-administration in animals, which suggests it may pose a higher risk for addiction, according to a 2018 paper published in Addiction Biology. Because of the higher risk, we also cover 7-hydroxymitragynine withdrawal on our website.
Mitragynine Pseudoindoxyl
Pseudoindoxyl belongs to a specific class of alkaloids known as spiro pseudoindoxyls. In humans, mitragynine pseudoindoxyl is formed as a metabolite through oxidative processes, particularly in the liver. This metabolite exhibits potent opioid receptor activity and plays a key role in the pharmacology in humans according to a 2020 study published in ACS Pharmacology & Translational Science. Pseudoindoxyl derivatives have been studied for their slow tolerance development and fewer side effects compared to traditional opioids.
You can learn more about the exciting developments of Pseudoindoxyl as we cover the developments on our website.
Upcoming Compounds
Though not as popular as the compounds prevously described, the next compounds we’ll cover are arguably equally important. They are the compounds that aren’t as quite popular yet, but are sure to show promise in the near-future.
Speciociliatine
Speciociliatine is one of the top most abundant compounds found inMitragyna speciosa. In dried leaves, this major alkaloid of the plant, makes up 3% of the leaf’s weight.
In 2002, an article published in The Journal of Medicinal Chemistry was the first to cover the discovery of speciociliatine in their study of the effects of alkaloid-rich compounds on guinea pigs.
Learning of the compound’s ability to block painful stimuli was discovered in 2020 Journal of Medicinal Chemistry article which provided the results of the study showing that speciociliatine is also more potent than morphine, though is less powerful compared to 7-hydroxymitragynine.
Paynantheine
Paynantheine is another prominent alkaloid that is gaining attention for its potential therapeutic properties. Research conducted in recent years has suggested that this compound may interact with multiple receptors in the brain, contributing to its promising therapeutic effects.
In a 2021 study published in Frontiers in Pharmacology, researchers demonstrated that paynantheine showed a significant reduction in pain behaviors in animal models. This research highlighted its dual-action potential, suggesting that paynantheine might not only alleviate pain but also provide some mood-enhancing effects, similar to those seen with other well-known alkaloids.
Another article published in FASEB Journal in 2021 paynantheine was shown to have the strongest binding to the human 5-HT1A receptor in an in vitro test using [3H]8-OH-DPAT. Paynantheine ranked second best (following speciogynine) for effectually inducing the strongest LLR effect with an ED50 value of 26 mol/kg. That’s why it’s being studied further to learn more about its effects.
Despite its relatively low profile compared to mitragynine and 7-hydroxymitragynine, paynantheine has shown itself to be a compound worth exploring further.
Mitraphylline
Mitraphylline is an active alkaloid in Mitragyna speciosa that shows potential in anti-inflammatory abilities according to a 2012 article published in Journal of Ethnopharmacology.
Mitraphylline also demonstrated neuroprotective properties, particularly in breaking down amyloid aggregates, which may indicate potential in treating Alzheimer’s disease as shown in a study published in 3Biotech in 2020.
Mitraphylline has potential to be recognized for its potency. A 2014 study published in Planta Medica showed that Mitraphyll ranked in the top 3 (following Mitragynine and 7-hydroxymitragynine) in terms of permeability with the intestinal barrier, showing promise for increasing the desirability to learn everything we can from this compound.
Corynoxine
As an inhibitor, Corynoxine has also shown potential for clearing out cellular waste according to a 2021 study published in Frontiers in Pharmacology.
Corynoxine also promotes autophagy and lysosomal activity, which helps reduce the buildup of amyloid-beta, potentially making it potentially useful in neurodegenerative cases according to a 2023 study published in The Indian Journal of Experimental Biology.
Speciogynine
Speciogynine is a stable, bioactive alkaloid iwith potential serotonin receptor activity and distinct metabolic pathways according to researchers.
It shows high affinity for serotonin receptors (5-HT1A and 5-HT2B), which may contribute to its physiological effects, including mood enhancement and relieving effects through non-opioid pathways according to a 2020 study published in the Journal of Analytical Toxicology.
Speciofoline
Unlike other alkaloids, speciofoline does not exhibit measurable binding affinity to opioid receptors, indicating it may not contribute to the opioid-like effects according to a 2020 article published in Scientific Reports.
Mitraciliatine
Mitraciliatine is a diastereomer of the alkaloid mitragynine, found in the plant Mitragyna speciosa. Mitraciliatine is metabolized similarly to other alkaloids in both rats and humans. It undergoes phase I and II metabolism, and its metabolites are detectable in human urine, confirming its presence after consumption according to a 2011 study published in Journal of Chromatography.
Corynoxine B
As an an oxindole alkaloid, Corynoxine B promotes autophagy (cellular waste clearance) and has been shown to reduce the levels of amyloid-beta proteins making it a promising candidate for neurodegenerative therapies according to some research.
According to a 2019 article published in Food and Chemical Toxicology, Corynoxine B was found to ameliorate autophagic dysregulation and prevent neurotoxicity by inhibiting the mTOR pathway. This highlights its protective role in neurological disorders related to environmental toxins in studies on manganese-induced neurotoxicity.
Corynantheidine
Corynantheidine is a minor indole alkaloid that shows moderate oral bioavailability and extensive extravascular distribution. It can be detected in brain tissues, indicating its potential role in modulating central nervous system activities according to a 2019 study published in The Journal of Pharmaceutical and Biomedical Analysis.
Ajmalicine
Ajmalicine is an indole alkaloid that is widely used as an antihypertensive drug, particularly effective in improving blood flow according to a 2012 article published in Medicine, Environmental Science, Biology.
Mitragynine Oxindole B
As an an oxindole alkaloid isolated from the leaves of Mitragyna speciosa, mitragynine oxindole B may contribute to the therapeutic and psychoactive effects due to its minor interactions with opioid receptors and its presence in various preparations according to a 2020 study published in ACS Chemical Neuroscience.
Tetrahydroalstonine
Tetrahydroalstonine is one of the many alkaloids that contribute to the plant’s complex pharmacological profile. This alkaloid shows potential neuroprotective effects by interacting with adrenergic receptors. It has been studied for its effects on the central nervous system, which include possible mood-enhancing and calming effects due to its adrenergic activity according to a 2020 study published in Journal of Natural Products.
Additionally, Tetrahydroalstonine’s effects on the adrenergic system make it of interest for treating conditions related to mood disorders and neurodegenerative diseases according to a 2023 study published in ACS Chemical Neuroscience.
Isopaynantheine
Isopaynantheine has been identified as a kappa-opioid receptor (KOR) agonist, which means it binds to and activates KOR, contributing to its potential pain-relieving effects. Importantly, it shows reduced recruitment of β-arrestin-2, which is associated with fewer side effects compared to other opioid receptor agonists, according to a 2021 study in ACS Chemical Neuroscience.
Isorynchophylline
Isorhynchophylline is known for its neuroprotective properties, particularly for its ability to promote autophagy, which helps in the degradation of harmful proteins such as α-synuclein showing that it has implications for the treatment of neurodegenerative diseases, according to a 2012 study published in Autophagy.
In addition to its neuroprotective effects, Isorhynchophylline acts on serotonin receptors, particularly the 5-HT2A receptor. This receptor modulation suggests potential benefits in mood regulation and sedation according to a 2005 article published in European Journal of Pharmacology.
Isospeciofoline
Isospeciofoline has been detected in pharmacokinetic studies of alkaloids in rats. However, its systemic exposure is typically low compared to other major alkaloids, indicating it may have a minor role in overall pharmacological effects, according to a 2021 study in Journal of Natural Products.
Mitragynine N-Oxide
Mitragynine N-Oxide is an oxidative derivative of mitragynine that forms as part of the oxidative metabolic pathway of mitragynine, creating distinct chemical and pharmacological properties according to a 2020 article published in The Journal of Natural Products.
Speciociliatine N-Oxide
Speciociliatine N-Oxide is an N-oxide derivative of speciociliatine, a minor indole alkaloid found in Mitragyna speciosa. N-oxides are known oxidative metabolites or derivatives of alkaloids that may have different pharmacological profiles compared to their parent compounds according to a 2020 article published in Journal of Natural Products.
Like other alkaloid N-oxides, Speciociliatine N-Oxide is expected to be a metabolite formed through oxidation in the liver. The pharmacokinetics and systemic exposure of this compound could differ from the parent alkaloid, speciociliatine, which has been shown to exhibit significant opioid receptor activity.
Alkaloid-contents are being studied as suitable alternative approaches to treatment, coping with psychological conditions and for substance abuse recovery.
Why Choose Advanced Alkaloids?
The average reported use of advanced alkaloids typically involves managing everyday stress, enhancing social situations through social lubrication, and promoting a sense of well-being. For these reasons, it is commonly referred to as a natural wonder.
Research suggests that alkaloids can provide a wide range of benefits. Its stimulant properties are often sought for increased energy, while others enjoy the calm and peace it provides, particularly for relieving anxious feelings. Many users report it being effective for managing hangovers and improving sleep.
Our products feature a blend of the most potent alkaloids that are known for their strong interactions with opioid receptors, providing antinociceptive activity and therapeutic potential. Our advanced formula is crafted to meet the stringent demands of the market, ensuring purity and potency.
We offer high-concentration alkaloids that are rigorously tested for quality. Our alkaloid extract is designed to provide consistent and reliable effects, making it ideal for commercial products. Each product undergoes extensive alkaloids testing and analysis, ensuring that you receive the highest quality and potency.
As a leading alkaloids supplier, we provide bulk alkaloids at competitive wholesale prices. Our alkaloids are available in bulk, ensuring you have a consistent supply to meet customer demand.
Join our wholesale program and gain access to the best advanced alkaloids for sale. With competitive pricing, premium quality, and a wide range of high-potency products, we can be your trusted partner. Register now to start benefiting from our superior product line and take your business to the next level.
We prioritize the integrity of our goods.
Our advanced formula is the result of extensive research and development, focusing on the optimal balance of alkaloids for maximum therapeutic potential. The molecular formula and interactions are carefully calibrated to enhance their effects and ensure consistent results.
Takeaway
For more information or to explore our range of advanced products, please contact us to get in touch with our customer support team.