The popularity of 7-hydroxymitragynine (7OH) resulted in more inquiries at 7OH Vendor to field questions on what people use for doses so this post is here to help give you a perspective on the topic, what we’ve learned and reasoning knowledge on the topic.
When it comes to serving amounts, because past 7-hydroxymitragynine dosage research mostly involves rats and dogs being the subjects of their academic studies, we mostly depend on independent experiments and feedback from customers (and ourselves) in noting results in humans. We’re hoping more conclusive direction is given by governing bodies, such as the FDA, soon.
When it comes to ingesting things for human consumption, governing bodies like to get involved to place it into a category. For example, “dose” could be considered a medical term which is restricted with one governing body, while “serving amount” could be considered a supplement term which is governed by another governmental body. We use terms interchangeably and that’s because we need a common naming convention to convey an idea — it shouldn’t be taken as a recommendation from a healthcare professional, though: as it’s a name to call something for how much is reportedly taken in a sitting.
We’re selling legal 7OH, but this shouldn’t replace advice from your healthcare provider. While we’re not healthcare professionals, we do interact with customers, vendors, and the public daily, and we have insights, based on research, that we believe are valuable to those who understand our perspective.
Overview
With any new ingestible, you want to know what to expect.
Though we can’t say with 100% assurance that you will have a great experience with 7OH products, most people that re-order do.
Before considering taking anything into your body, you want to do your own research and check with a doctor.
With all the boxes checked off, 7-hydroxy mitragynine (7OH) is most effectively administered in tablet-form. The approximate 7-hydroxymitragynine amount of the tablet to take is 1/2 or less of the tablet up to 1 whole tablet, depending on which 7-OH Products you are using.
Since effects are felt fully around 30 minutes after administration, you’ll know quickly whether it was the right amount for you.
The most popular dose for beginners is 1/2 tablet using competitors’ products, though the amoung is one whole tablet for easy use with 7OH Vendor’s Pill Tabs. Amounts can differ depending on users’ needs and health provider’s recommendation.
We’ll look at both the research and findings regarding dosage so it can be considered in the final determination regarding taking 7-hydroxymitragynine (7OH).
7-hydroxymitragynine Dosage Findings
The single dose question for 7OH has been stumping researchers for years, but they are making progress and getting closer in determining the answer.
7-hydroxymitragynine is a key active metabolite derived from mitragynine, the primary kratom alkaloid found in mitragyna speciosa. This major alkaloid has shown pharmacologically significant properties, acting on mu opioid receptors and δ opioid receptors as a partial agonist with low efficacy agonist activity. 7-hydroxymitragynine is notably more potent than mitragynine and has been identified in various kratom products, contributing to their opioid-like effects.
The 7-hydroxymitragynine (7OH) dose plays a crucial role in determining its effects. Low doses of this alkaloid can exhibit dose-dependent stimulant and analgesic effects, while high doses can lead to sedative effects and adverse outcomes such as physical dependence and drug withdrawal symptoms that strongly resemble opioid withdrawal. The intermediate doses may offer a balanced effect, but high and aversive doses could increase the risk of drug abuse and adverse events such as respiratory depression.
Research in animal studies, particularly with male and female rats, has provided significant insights into the pharmacological impact of 7OH. These studies often utilize the intracranial self-stimulation procedure to assess brain reward thresholds and the effects of opioid receptor modulators. Additionally, in vitro assays have been instrumental in evaluating the serotonin receptors and the role of inhibiting serotonin synthesis in the brain’s response to this alkaloid.
Given the complexity of its effects, kratom use involving 7OH requires careful consideration, especially in kratom products that are marketed as natural alternatives. The dose-dependent nature of 7OH underscores the importance of clinical pharmacokinetic assessments and a thorough understanding of drug interactions to mitigate potential health risks associated with high doses or chronic use.
The effects of mitragynine are becoming clear to researchers, though. Mitragynine, the principal alkaloid found in Mitragyna speciosa, exhibits a range of effects due to its interaction with various receptors in the body.
Rewarding effects
- According to a study published by Journal of the American Chemical Society in 2016, researchers presented Mitragynine has been shown to act as a partial agonist at the mu-opioid receptors, similar to traditional opioids. This action results in analgesic (pain-relieving) effects, although it is considered less potent than morphine, while 7-OH (derived from Mitragynine_ is now considered to be more potent that morphine. Mitragynine also acts as a competitive antagonist at the kappa- and delta-opioid receptors, which may contribute to its unique pharmacological profile, according to their research.
- Research has shown that mitragynine can effectively reduce withdrawal symptoms in morphine-dependent rats. The 2014 study published in Addiction Biology found that mitragynine (at doses of 5–30 mg/kg) was able to mitigate acute withdrawal signs, suggesting that it may serve as an alternative treatment for opioid withdrawal, comparable to methadone and buprenorphine
- A 2021 study published in Frontiers in Pharmacology showed that mitragynine has been shown to be less potent than methadone and buprenorphine in mitigating opioid withdrawal symptoms. However according to the study, it still presents a viable alternative, particularly for individuals seeking non-traditional therapies
- A 2022 study published in Frontiers in Pharmacology showed the compound has been noted for its ability to alleviate chronic discomfort, making it a potential alternative to traditional opioids, especially in cases where the risk of addiction is a concern.
As research continues, we’re starting to understand more about rewarding effects of dosage as it relates with the body, however, there are some important adverse effects to consider, too, from the research thus far.
Adverse effects
- In a 2016 article published by Toxicology and applied pharmacology (Volume 305), researchers showed. that mitragynine has been associated with potential cardiotoxic effects. It has been shown to inhibit specific cardiac potassium channels (hERG), which can lead to prolonged QT intervals and increased risk of arrhythmias, thereby raising concerns about its safety at higher doses
- Going back to an older study in 2002 published by The European Journal of Pharmacology it presented research that indicates that mitragynine can affect gastric acid secretion, acting through opioid receptors in the central nervous system (CNS). This can lead to both inhibitory and stimulatory effects on gastric acid production depending on the specific opioid receptor subtype engaged.
- A 2015 study published in Addiction Biology showed that mitragynine exhibits properties that suggest a potential for addiction and withdrawal, similar to other opioids. Studies have shown that it can lead to conditioned place preference and sensitization, indicating its ability to induce rewarding effects and dependence.
The potential adverse effects can’t be ignored. As research continues, below are some of the findings from more studies to give you an idea of the direction research is headed.
Where is 7OH Dosing Research headed?
As a possible treatment of opioid withdrawal, though knowingly has potential for causing adverse effects, we’re interested to know where academic research is headed, especially for the more broader category of therapeutic potential.
Acknowledging the abuse potential in humans, so far, researchers have focused their studies on testing the effects of drugs on animals.
Below are some the examples of this type of research thus far:
- In a 2006 article published by The European Journal of Pharmacology researchers suggest 7OH has been found to be significantly more potent than morphine, with dose-dependent antinociceptive (pain-relieving) effects. In mouse models, subcutaneous administration of 7OH demonstrated antinociceptive effects that were 5.7 to 4.4 times more potent than morphine in tail-flick and hot-plate tests, respectively. The ED50 values for these effects were 0.80 mg/kg and 0.93 mg/kg according to researchers.
- In a 2004 article published by The European Journal of Drug Metabolism and Pharmacokinetics, researchers showed that in dogs, when administered orally, 7OH was rapidly absorbed after oral administration, with a peak plasma concentration observed within 15 minutes. The elimination half-life was approximately 3.6 hours, indicating that the compound remains active in the body for an extended period and retained its potent analgesic properties. In particular, doses of 5-10 mg/kg were effective in inducing antinociceptive effects in mice, surpassing the efficacy of orally administered morphine.
Below are some perspectives from the community on dosage:
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All considered, accurate dosing for 7-hydroxymitragynine hasn’t been determined quite yet by experts.
Takeaway
We’re all awaiting a time where clear instruction from professionals will be able to inform our decisions on 7-hydroxymitragynine intake, however, until then, we must keep an open-mind as to the amounts and types of products considered until more definitive research is gathered.
We’re always seeking to learn more about the dose findings. If you have some remarkable research that you’d like to be considered for the overview, please feel free to contact us to submit your study.