You might’ve heard Mitragyna Speciosa and its potent alkaloids. Maybe your friends have used it, perhaps you read the Reddit forums about it, or maybe you’re even considering other ways to utilize the opportunity to learn more about this powerful alkaloid. Whatever your end goal, we’ll help you understand all about it.
7-Hydroxymitragynine is a highly potent indole alkaloid that has been extensively studied for its remarkable analgesic effect. As a structurally unique opioid agonist, 7-Hydroxymitragynine offers pain relief that is both effective and distinct from traditional opioid medications. This compound is a key component of Mitragyna speciosa, a promising medicinal plant used for centuries in Southeast Asia, now gaining attention as a potential alternative for managing discomfort while providing euphoria for the user.
That’s been the promise anyway, and studies are underway to see to what extent 7-Hydroxymitragynine can help us in our every day lives. Though it’s showing promise, it’s not legal everywhere and governing bodies are determining how it should be regulated in the near future.
Welcome to 7OH Vendor‘s Guide on 7-hydroxymitragynine! As your trusted source for premium products, in this guide, we’ll explore what 7-hydroxymitragynine is, its benefits, and why it stands out in the market.
What is 7-Hydroxymitragynine?
7-Hydroxymitragynine is a naturally-occurring metabolite found in the leaves of the Mitragyna speciosa plant. It is highly valued for its analgesic and relaxing properties.
Unlike traditional opioids, it interacts with mu-opioid receptors in the body, offering potent effects without some of the risk of severe side effects with opioids, for most people.
C23H30N2O5 is the scientific chemical formula for 7-Hydroxymitragynine.
7-Hydroxymitragynine is an indole alkaloid derived from the tropical tree, Mitragyna speciosa. This emerging botanical agent has garnered significant attention in the scientific literature for its potent analgesic effect, which makes it a promising alternative for treating chronic pain and opioid use disorder– though, we are awaiting studies to confirm this.
Unlike typical opioids, 7-Hydroxymitragynine possesses an atypical molecular framework, giving it unique pharmacological activity as an orally active opioid analgesic. However, its structural similarity to opioid agonists like mitragynine and other opioid ligands raises important questions about its safety, efficacy, and abuse potential.
7-Hydroxymitragynine exerts its powerful effects primarily through its action as an orally active opioid analgesic. It interacts with multiple opioid receptors, including the κ opioid receptor and δ opioid receptor. As an human µ opioid receptor modulator, it functions as a partial agonist at these sites, offering potent opioid agonistic activities while potentially reducing some of the adverse effects commonly associated with full opioid agonists.
Its interaction with simulated gastric fluid and the subsequent absorption and metabolism highlights its competitive antagonist activity in certain contexts. Additionally, the compound’s influence on opioid receptor antagonists and its role in opioid receptor signaling make it a significant subject in the study of opioid-related drug interactions.
Is mitragynine considered an opiod?
Mitragynine is classified as an atypical opioid due to its interaction with opioid receptors and its ability to produce opioid-like effects. However, its distinct receptor activity profile sets it apart from traditional opioids.
7-OH doesn’t trigger the same pathways as regular opioids, though it’s showing promise to prompt cases that are less likely to cause serious side effects like trouble breathing, constipation, extreme drowsiness or other similar adverse effects.
Because 7-Hydroxymitragynine functions as a partial agonist at receptors, this interaction results in a powerful antinociceptive effect, providing remarkable relief from discomfort with potentially fewer adverse events compared to other drugs. The alkaloid also exhibits significant binding affinity and opioid agonistic activities, making it a subject of interest in receptor signaling explorations. However, in vitro studies and rodent models suggest that its interaction with the κ opioid receptor, and the μ opioid receptor may contribute to both its analgesic effects and rewarding effects, indicating a possible abuse liability.
Is 7-hydroxymitragynine a full antagonist?
No, 7-hydroxymitragynine is considered a partial antagonist at the mu-opioid receptors (MOR).
This means that while 7OH activates the MOR, it does so to a lesser extent than full agonists like morphine. Specifically, studies have shown from a 2019 article in ACS Central Science publication that 7OH exhibits strong agonistic activity, which is more potent than that of solely the mitragynine alkaloid from Mitragyna speciosa by itself.
What are the pure opiod antagonists?
The most popular pure opiod antagonists, include: Naloxone, Naltrexone, Nalmefene, Methylnaltrexone, and Alvimopan.
Pure opioid antagonists are compounds that block the effects of opioid agonists by binding to receptors without activating them. These antagonists are used to reverse the effects of opioid overdose, manage opioid dependence, and mitigate the side effects of opioid therapy.
What is the active ingredient in mitragynine?
Mitragynine itself is the active ingredient. Mitragynine is the major alkaloid found in the leaves of the Mitragyna speciosa plant and is responsible for most of the plant’s psychoactive effects.
As an indole alkaloid, mitragynine is the most abundant of the various alkaloids found in those leaves.
What are the different types of mitragynine?
Mitragynine itself is a distinct alkaloid, but there are several related compounds or derivatives, such as 7OH, mitragynine pseudoindoxyl, and other related alkaloids like speciogynine, paynantheine, and speciociliatine.
What is 7 hydroxy?
“7-Hydroxy” refers to the chemical structure of a compound where a hydroxyl group (-OH) is attached to the seventh carbon atom of the molecule. This structural modification can significantly alter the compound’s pharmacological properties compared to its parent compound.
7-Hyrdoxy is most commonly associated with 7OH. This specific compound is a metabolite and a more potent derivative of mitragynine.
Is 7-Hydroxymitragynine synthetic?
No, 7OH is not synthetic. It is a naturally occurring alkaloid found in a plant. This compound is one of the many alkaloids present in Mitragyna speciosa, and it is formed naturally within the plant.
However, 7OH can also be synthesized in the lab, too, to replicate results originating in nature.
The most popular way 7-OH is taken is in tablet form. Some people remark about the bitter alkaloid taste, but: it’s temporary. Effects can be felt anywhere from minutes to an hour after ingestion.
What are its effects and benefits?
Users leave remarks about the common effects of 7-OH relieving discomfort, sedation, and its euphoric properties. Benefits range from managing everyday discomfort, feeling more stressfree and as an alternative approach to opioid withdrawal — though, more research is needed to confirm any of these.
Since 7OH is a fairly new commercial product, and while science gives us more evidence to support its claims, we lean on first-hand experiences of using the product.
Such as: did you know 7-OH can sometimes give the munchies?
What is mitragynine used for?
The utility of mitragynine works as a near instant relief mechanism for entering into a more euphoric state, providing a different way of living momentarily in the grand scheme of things, but enough to remember what it felt like, which can become quite addicting– that’s why you have to be careful out there, first and always.
Below is a table with more details on the supposed effects and benefits as we know of them today.
| Effects | Benefits |
| Analgesia (Pain Relief): 7OH is known for its powerful analgesic effects, which are significantly more potent than those of morphine on a per-weight basis. It acts primarily on mu-opioid receptors in the brain, which are the same receptors targeted by traditional opioid medications. | Alternative Pain Management: 7OH presents a potential option as an alternative. Its natural origin and its potent relieving effects make it a possible alternative for those managing pain, though more scientific research needs to be published to back-up this reasoning. |
| Sedation: At higher doses, 7OH can induce sedation, which can help with relaxation and sleep. This effect is similar to that of other opioids and is often sought by users for its calming properties. | Support in Opioid Withdrawal: 7OH may help reduce withdrawal symptoms in individuals trying to taper off stronger opioids. Its ability to activate receptors can alleviate some of the discomfort associated with opioid withdrawal, studies are underway to describe more. |
| Euphoria: Like other opioids, 7OH can produce feelings of euphoria. This effect is due to its action on the brain’s reward pathways, which is also why it has the potential for abuse and dependency. | Reduction of Anxiety: At certain doses, the calming and sedative effects of 7OH can help reduce everyday anxious feelings and promote a sense of well-being. |
| Antitussive (Cough Suppression): There is some evidence to suggest that 7OH may have antitussive properties, similar to other opioids, meaning it could help in suppressing coughs. | Potential for Less Respiratory Depression: Compared to traditional opioids, there is some evidence to suggest that 7OH may cause less respiratory depression, one of the most dangerous side effects of opioid overdose. However, this benefit is still under investigation and should be approached with caution. |
CAUTION: Despite its benefits, 7OH shares many of the risks associated with traditional opioids, including the potential for dependency, tolerance, and withdrawal. Users should approach this compound with caution, particularly if used regularly or at higher doses.
Mitragynine and its active metabolite, 7OH, are metabolized primarily by human liver microsomes, with CYP3A4 being one of the key enzymes responsible for this process. Understanding the metabolite profiling and retention time is crucial for assessing potential drug interactions and the overall health impact of this compound. In vitro studies have shown that 7OH can act as a competitive antagonist at certain receptors, particularly when co-administered with other opioid ligands. This raises concerns about its use alongside other drugs, especially those that are opioid receptor antagonists or have a high potential for respiratory depression.
How does mitragynine affect the brain?
Chronic consumption of mitragynine has been shown causing “cognitive deficits” of the brain in lab rats, according to a 2021 article in The Neuroscience Letters (Volume 745).
Mitragynine, the principal alkaloid in Mitragyna speciosa, affects the brain primarily through its interaction with receptors. Its effects on the brain are complex and can lead to both therapeutic benefits and potential risks. Here are the key findings on how mitragynine affects the brain:
- Opioid Receptor Interaction: Acting as a partial agonist at the mu-opioid receptors, which are responsible for its analgesic (pain-relieving) effects. This interaction is similar to that of traditional opioids, but mitragynine’s action is less potent, leading to reduced risk of respiratory depression, which is common with stronger opioids, according to researchers in their 1996 article published in Life Sciences, which has informed decades of similar research since.
- Cognitive Effects: Chronic exposure to mitragynine has been shown to impair cognitive functions, including spatial learning and memory. This is possibly due to its effects on synaptic transmission in the hippocampus, a brain region critical for memory formation, according to researchers in their 2019 article published in Journal of Psychopharmacology, which alarmed many in the industry spawning more studies conducted.
- Potential for Abuse and Dependence: Mitragynine has been found to possess addictive properties similar to other opioids, including the ability to induce conditioned place preference and locomotor sensitization in animal studies, which are indicators of potential for abuse according to researchers in their 2015 article published in Addiction Biology.
Mitragynine affects the brain by acting on receptors, leading to relief and potential cognitive impairments with chronic use. It also alters brain activity and has addictive properties, which make it similar to other opioids in terms of its potential for abuse and dependence.
Does mitragynine affect the blood brain barrier?
Yes, it does have the ability to affect the blood-brain barrier by crossing it.
Mitragynine is a lipophilic compound, meaning it can cross the blood-brain barrier. Studies using in vivo models have shown that after administration, mitragynine can rapidly penetrate the BBB and accumulate in brain tissue. This suggests that mitragynine has good BBB permeability, which is critical for its central nervous system effects.
How strong is 7 mitragynine?
7OH is a highly potent alkaloid. 7OH is estimated to be approximately 13 to 46 times more potent than morphine in terms of its analgesic (pain-relieving) effects when tested in animal models, according to researchers in their 2019 article published in ACS Central Science.
How is 7-hydroxymitragynine made?
Generated from mitragynine in vivo by hepatic metabolism, 7OH is made both by nature, and can be then produced by man.
It is not synthesized in a laboratory under natural conditions but is instead produced within the plant through natural biosynthetic processes.
Here are the ways it’s made:
| 1 | 2 | 3 |
| Biosynthesis | Extraction from Mitragyna speciosa Leaves | Laboratory Synthesis (Synthetic Pathway) |
| 7OH is formed from mitragynine, the primary alkaloid in Mitragyna speciosa. Within the plant, specific enzymes catalyze the hydroxylation of mitragynine at the 7th carbon position, converting it into 7OH. This process is a part of the plant’s natural alkaloid biosynthesis pathway. | 7OH is present in Mitragyna speciosa leaves, but in much lower concentrations compared to mitragynine. The compound is typically extracted along with other alkaloids during the processing of Mitragyna speciosa leaves. | Although 7OH is naturally occurring, it can also be synthesized in the laboratory for research purposes. The synthetic process generally involves the chemical modification of mitragynine, using hydroxylating agents to specifically target the 7th carbon position and add the hydroxyl group. This synthetic approach allows for the production of 7OH in a controlled environment, often for study and analysis. |
7OH is primarily produced in nature through the enzymatic conversion of mitragynine within the Mitragyna speciosa plant. It can be extracted from Mitragyna speciosa leaves or synthesized in a laboratory for research purposes. This natural conversion makes it a key secondary metabolite in Mitragyna speciosa, contributing significantly to the plant’s pharmacological effects.
What is 7-hydroxymitragynine HCL?
7-Hydroxymitragynine HCl (hydrochloride) is a chemical form of 7OH, which is a potent alkaloid found in the Mitragyna speciosa plant. The “HCl” denotes that the compound has been converted into its hydrochloride salt form. This conversion typically involves the addition of hydrochloric acid to the base compound, 7OH, resulting in a more stable and soluble form.
What is the bioavailability of mitragynine?
Bioavailability ranges around around 3.03% to 21% depending on the study and specific conditions under which it was tested.
The 3.03% minimum is taken from a 2010 article published in Analytical and Bioanalytical Chemistry with their study on rats.
The 21% taken from a 2019 article published in Asian Journal of Psychiatry in which the article reviewed 17 related studies and said, “In rats and humans, mitragynine is rapidly absorbed after orally administration (Tmax˜1.5 h, Cmax˜0.3−1.8 μM). Vd was 37–90 L/kg; t1/2 was 3–9 hr; mostly excreted as metabolites in urine. Bioavailability was estimated as 21%,” according to that study.
7-hydroxymitragynine Half Life
The ratio of 7OH to mitragynine in the blood is higher after a single dose compared to multiple doses, suggesting the body may process these compounds differently with repeated use, according to a study in the 2024 for the Special Issue of Mass Spectrometry in Life Sciences Dedicated to Professor Gérard Hopfgartner.
According to their research, “Mitragynine and 7-hydroxymitragynine terminal half-lives generally increased with increasing doses, as concentrations were measurable for longer at higher doses compared to lower doses,.” researchers Huestis, Martin, Brett, John Bothmer and Atallah — all signifying the need more definitive answers for determining an industry standard to use in the future.
What is the toxicity level of mitragynine?
The toxicity of mitragynine has been a subject of research, particularly concerning its potential harmful effects at higher doses.
In a study with rats, when they were given mitragynine at doses of 1, 10, and 100 mg/kg over 28 days, none of the rats died according to researchers in their 2013 article published in Journal of Ethnopharmacology. However, at the highest dose (100 mg/kg), there were some signs of toxicity. The rats lost weight, ate less food, and had an increase in liver size. Additionally, there were noticeable changes in their liver, kidneys, and brain, which showed that mitragynine can cause harmful effects at high doses.
Research has shown that mitragynine can affect cardiac function by blocking specific potassium channels in the heart, which can lead to cardiotoxic effects such as arrhythmias according to researchers in their 2016 article published in Toxicology and Applied Pharmacology. This suggests that mitragynine, particularly at higher doses, may pose a risk to heart health.
Mitragynine has been implicated in several forensic toxicology cases, particularly in contexts of drug overdose and fatalities. The reported toxic and potentially lethal concentrations of mitragynine in human blood vary, with some studies indicating fatal outcomes at blood concentrations as low as 950 ng/mL, especially when combined with other substances.
However, we’re still waiting to see just one overdose case where other drugs weren’t found during the autopsy!
Is mitragynine basic or acidic?
Mitragynine is acid-labile, as it is considered a basic compound.
This is because it contains an amine group, which is a nitrogen atom that can accept a proton (H+), making it a proton acceptor or base according to the Brønsted-Lowry definition of acids and bases. The basicity of mitragynine is typical of alkaloids, which are nitrogen-containing compounds that often have basic properties. This basic nature also influences how mitragynine interacts with the body, including its solubility and absorption.
What enzyme metabolizes mitragynine?
Mitragynine is primarily metabolized by the cytochrome P450 (CYP) enzyme system in the liver, with CYP3A4 being the most significant enzyme involved in its metabolism according to both articles, a 2019 article in General Xenobiochemistry and a 2020 article in Journal of Analytical Toxicology.
What are some of the practical uses for 7-hydroxymitragynine?
People have their own various reasons for taking a 7-OH, doing that lifestyle.
The therapeutic potential of 7-Hydroxymitragynine (7OH) as an alternative to traditional medicine for treating chronic pain is significant. Its greater potency compared to mitragynine, along with its promising analgesic effects, makes it an attractive candidate for further research and future clinical studies. However, the scientific data also highlight the need for caution. The compound’s reinforcing effects and potential for physical dependence must be carefully monitored, particularly in human subjects who may be at risk for opioid addiction or use disorder.
Alternative Medicine benefits from 7OH. Showing potential as a Therapeutic Alternative, researchers have showed its promise since their 2005 article in Life Sciences which they found that given its strong analgesic effects, 7OH has been investigated as a possible alternative to traditional opioids for pain management, especially in situations where conventional opioids are either not effective or desirable.
Additionally, a 2006 article in The European Journal of Pharmacology proposed 7OH has been shown to inhibit gastrointestinal transit in a manner similar to morphine, although it appears to be less constipating. This effect can be beneficial in certain medical contexts where slowing gastrointestinal transit is desirable.
The analgesic effect of 7OH makes it an attractive option for those seeking to treat pain without resorting to conventional opioids. As a dietary supplement and a component of traditional medicine, it is often administered orally in a controlled dose range. The compound’s potential as a new indole alkaloid offers exciting possibilities for future therapeutic applications.
Research into the chemical composition of mitragynine and 7 hydroxymitragynine content reveals that these alkaloids constitute a significant portion of the plant’s pharmacologically active compounds. The exploration of oral mitragynine and its related alkaloids provides valuable insights into its neurochemical characterization and therapeutic potential.
While 7OH offers significant therapeutic potential, it is important to recognize the risks associated with its use. The compound’s interaction with receptors can lead to withdrawal symptoms and drug abuse if not carefully managed. The role of human liver microsomes in metabolizing 7OH underscores the need for caution, especially in individuals with compromised liver function or those taking other medications.
Which 7-hydroxymitragynine percentage ranges are best?
Most natural Mitragyna speciosa leaves contain very low levels of 7-Hydroxymitragynine, typically around 0.01% to 0.04% by weight.
Considering that the concentration of alkaloids in the leaves can range between .5% at the low end, up to 1.5% of the leaf material means that comparatively to the other alkaloids which must make up the difference, it is naturally found in lesser amounts in nature.
Whether you treat 7OH as a pack of Condition-specific Supplements, Herbal Supplements, Sports Health and Nutrition or for general Health and Wellness, be careful what you call it: because the legalities matter in this case.
Legality of 7-hydroxymitragynine
Given the emerging popularity of 7-Hydroxymitragynine (7OH) in concentrated extracts and dietary supplements, quality control and safety regulations are paramount. The Drug Enforcement Administration and other regulatory bodies have warned consumers about the potential adverse events associated with misuse. The alkaloid concentrations in leaf extracts can vary widely, and without proper standardization and scientific understanding, there is a risk of unintended health consequences. Therefore, it is crucial to establish a clear lower limit and maximum concentration for safe use, supported by robust clinical studies and scientific literature.
The legality of 7OH, one of the key active compounds in Mitragyna speciosa, varies across different countries and jurisdictions:
- In the United States: 7-Hydroxymitragynine (7 OH) is not federally controlled, but its legal status is complex. The FDA has not approved Mitragyna speciosa or its compounds for any medical use. Some states have implemented their own regulations or bans on Mitragyna speciosa and its alkaloids
- Some states have banned Mitragyna speciosa alkaloids, including 7 OH, while others have implemented regulations.
- For instance: Alabama, Arkansas, Indiana, Rhode Island, Vermont, and Wisconsin ban mitragynine and 7 OH
- Some states like Arizona, Oklahoma, Texas, and Utah prohibit the sale of Mitragyna speciosa products where 7 OH levels exceed certain thresholds
- Some states have banned Mitragyna speciosa alkaloids, including 7 OH, while others have implemented regulations.
Also check your local laws since some municipalities have their own laws on top state laws, which adds an extra layer of complexity in navigating the legalities.
Ongoing studies and functional assays are essential for understanding the full scope of 7 OH’s effects. Detailed drug evaluation and scientific literature have shed light on its opioid agonistic activities and the role of competitive antagonists in modulating its effects. The alkaloid content in the concentrations of mitragynine and 7 OH, remains a critical focus of research.
Further exploration into human liver microsomes and metabolite profiling is needed to clarify the compound’s metabolism and potential drug interactions. Understanding these interactions is crucial for assessing the safety and efficacy of 7 OH as a dietary supplement and in other therapeutic contexts.
Where to Buy 7-hydroxymitragynine
It can be purchased both online and in-store.
For online orders, you won’t need to worry about traveling around to local stores because it can ship the product directly to you.
Takeaways
When considering 7-OH, it’s important to weigh the potential benefits against the considerations involving individual health factors, local laws, new research and discoveries, plus more in this ever-changing industry.
Given the emerging popularity of 7-Hydroxymitragynine in concentrated extracts and dietary supplements, quality control and safety regulations are paramount. The regulatory bodies have warned consumers about the potential adverse events associated with misuse. The alkaloid concentrations in leaf extracts can vary widely, and without proper standardization and scientific understanding, there is a risk of unintended health consequences. Therefore, it is crucial to establish a clear lower limit and maximum concentration for safe use, supported by robust clinical studies and scientific literature.
We hope you learn a lot in this short guide and it was fun to provide you with a lot of the information to help you along your way. We’re here to supply the best product, so this kind of material is near and dear to us– we hope you enjoyed and will consider us for your next order.
If you have any questions about 7-OH products or placing an order, feel free to contact for immediate support.